Vulvar leukoplakia is a kind of lesion with pigmentation change and degeneration of female vulvar skin and mucous membrane tissues, which may usually show symptoms such as vulvar itching, rupture, severe pain and skin changes. Usually topical drugs such as glucocorticoid preparations and immunosuppressants can be used under the guidance of doctors to control itching and restore the normal form of lesions: 1. glucocorticoid preparations: glucocorticoid ointments such as clobetasol propionate ointment and tretinoin acetate cream can be used to resist inflammatory reactions, control itching and prevent further deterioration; 2. immunosuppressants: immunosuppressants such as tacrolimus ointment and pimecrolimus cream can be used to 3, sex hormone preparations: topical drugs such as ethylene estradiol ointment and testosterone propionate can relieve vulvar leukoplakia caused by estrogen deficiency; 4, antibiotic preparations: if accompanied by infection, antibiotic preparations such as neomycin fluorescence cream and erythromycin ointment can be used for anti-inflammatory and anti-infective treatment; 5, vitamin preparations: vitamin A cream can be used for local Vitamin A cream can be applied to improve the dryness and cracking of vulva and relieve the symptoms of vulvar blemishes such as rupture and pain. If the symptoms are serious or drug treatment is ineffective, physical therapy can be adopted, commonly used methods include focused ultrasound, liquid nitrogen freezing, etc. For patients with obvious symptoms or malignant changes, surgical treatment is required.