1.What is ankylosing spondylitis? Ankylosing spondylitis is an autoimmune disease that mainly manifests as inflammation of the spinal joints. Patients will gradually experience pain and stiffness in the spinal joints, and eventually the intervertebral joints will gradually harden and fuse, and many patients will progress to hunchback. If left untreated, the disease can also involve other joints and even many organs such as the heart, eyes, and kidneys. The disease occurs in young men and is often prolonged, causing much suffering to the patient. There is no cure for the disease, and treatment is usually focused on relieving symptoms and preventing disability. Commonly used drugs are non-steroidal anti-inflammatory drugs, although these drugs do not slow down the deterioration of the disease. 2.What is Classic? Classic is a mono-antibody against tumor necrosis factor type A (TNF-α), which neutralizes TNF-α in the body and prevents it from exerting its immunological effects. We know that ankylosing spondylitis is an autoimmune disease, which means that the body’s immune system is abnormally activated, causing the immune system to attack itself to stop the phenomenon. In the process of abnormal activation of the immune system in patients with ankylosing spondylitis, TNF-α, a substance that plays a very large role, can mobilize a large number of lymphocytes to attack the patient himself, thus causing the disease. The application of monoclonal drugs such as classical grams can significantly relieve the symptoms of stiffness and pain in the joints of patients, thus improving the quality of survival. 3. Why can’t tuberculosis patients use classical grams? As mentioned earlier, TNF-α can mobilize lymphocytes to attack normal tissues. But conversely, if the body is invaded by pathogens, then TNF-α is also a means for the body to mobilize lymphocytes for self-defense. More importantly, lymphocytes play a dominant role in immunity to tuberculosis, wrapping up inflammation and preventing further spread and aggravation of the tuberculosis bacteria. The use of Tricor suppresses TNF-α and the activity of lymphocytes, so the use of Tricor in TB patients with uncontrolled infection can have disastrous consequences. If you look at the official website for Tricor, it clearly states – there have been reports of serious infections such as tuberculosis and sepsis in users, some of which are life threatening. If you have been exposed to TB in the past or recently, you should inform your doctor. If your body is susceptible to infection, if you have been or have been infected, or if you develop symptoms of infection while using steroids, you should see your doctor immediately. Therefore, it is completely correct and responsible for patients infected with tuberculosis not to use classical grams. 4. Can tuberculosis patients only say no to the analogues? After centuries of tireless efforts, TB is no longer an incurable disease. Although there are still challenges such as drug resistance of tuberculosis bacteria, most patients are cured after 6 months of standard anti-TB treatment. Due to the limitations of general hospitals, patients with active TB must be treated in specialized TB hospitals. And, as a rule, all anti-TB treatment is paid for by the government and the patient does not have to pay for it. In summary, in this case, the doctor’s recommendation that the murderer first go to a specialized hospital for TB treatment and then return for treatment with classical grams was not only reasonable but also wholeheartedly for the murderer’s sake. The killer had nothing to lose by treating his tuberculosis first; the cost of anti-TB treatment was completely covered by the government, while the cost of the treatment with analogs, although expensive, was reimbursed by the current health insurance for the vast majority of his treatment. How different everything would have been if the killer had not been overwhelmed by irrational emotions and committed an unforgivable crime. Perhaps the murderer would have been starting standard anti-TB treatment by now, and would have been able to begin classical gram treatment six months later, and would have been able to live a near-normal life for a long time to come. And the deceased Dr. Wang has successfully graduated with a master’s degree and will be able to continue his training in Hong Kong in the second half of the year, and will be a good doctor on his own in a few years. The young female doctor with facial penetrating injuries, originally perhaps a few months later to find the one in his life, to start a sweet romance …… and things have come to a head, all this beautiful vision is like a bubble broken, leaving only a death and three injuries, a person in jail, and two broken families.