Leukoarai syndrome is a systemic vasculitis that mainly manifests as recurrent oral ulcers, genital ulcers, ophthalmia and skin damage, and can also involve the nervous system, gastrointestinal tract, cardiovascular, and epididymis. The cause of this disease is unknown, may be closely related to infection, genetics, environment, immunity, clinical manifestations are: 1, general symptoms: mild or occasional weakness, joint pain, dizziness and headache, loss of appetite, weight loss, etc.; 2, oral ulcers: recurrent, can be single or multiple, scattered distribution in the oral cavity, heavy ulcerative stomatitis, ulcers deep scarring, pain, affect eating, often accompanied by infection; 3, genital ulcers: recurrent, can be single or multiple, scattered distribution in the oral cavity, ulcerative stomatitis, ulcers deep scarring, pain, affect eating. 3, genital ulcers: recurring, mostly in the scrotum, penis and ghost head in men, and in the labia and perianal area in women, with significant pain, but no pain when it appears in the cervix. 4, skin damage: more manifestations, the most typical and common are pseudofolliculitis, erythema multiforme, erythema nodosum; 5, eye damage: recurrent uveitis and retinal vasculitis, in severe cases there may be macular edema, vitreous clouding, glaucoma, cataract, etc.; 6, involvement of other systems may be: joint damage, heart and macrovascular damage, neurological damage, lung damage, kidney damage, etc. The treatment of leukoaraiosis syndrome is mainly to control the existing symptoms, prevent and control important organ damage, slow down the disease progression, etc.