Cipro belongs to a new class of antidepressants, namely selective 5-hydroxytryptamine reuptake inhibitors, which are widely used in clinical practice. The antidepressant effect of these drugs is comparable to that of traditional tricyclic antidepressants, but the safety profile is high, the chance of adverse effects is relatively small, and the impact on the work and life of depressed patients is low. Nevertheless, the adverse effects of SSRI drugs, such as gastrointestinal reactions, sleepiness, and increased agitation, may appear soon after taking the drugs, but their efficacy will gradually appear only after 2-3 weeks of continuous use, so the physical discomfort you experience is a normal phenomenon, which will gradually decrease or even disappear with the extension of treatment time, and the efficacy of the drugs will gradually appear, which is exactly the same. It can be said that “there will be a village in the dark”. Generally speaking, the initial effect of antidepressants may be the improvement of sleep and appetite, then the energy and physical strength will gradually recover, and finally the depression will improve, so after two or three weeks, the effect of drugs does not mean that the depression symptoms will be significantly relieved. For now, for you, it is a matter of sticking to the medication, actively treating it, patiently waiting for the medication to take effect, and at the same time, not relying completely on the medication, trying to maintain a normal lifestyle, appropriately lowering your demands for work, increasing your initiative in treating the disease, and doing what you can to do in your current depressed mood. Of course, not all patients can benefit significantly after taking antidepressants, the general effectiveness of SSRI antidepressants is about 70%, if you still have no significant effect or poor effect after a full dose and full course of antidepressant treatment, you may need to see a professional medical institution again to see if you need to adjust the treatment plan.