Alcoholic liver disease is a disease of the liver caused by prolonged and heavy drinking. Alcoholic liver disease includes mild alcoholic liver disease, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. In recent years, the incidence of alcohol-induced liver damage in China has been on the rise year by year, and alcohol has become the second largest cause of liver damage after viral hepatitis. Alcohol has obvious toxic effects on the liver. The main metabolite of alcohol is acetaldehyde. Acetaldehyde can covalently combine with a variety of proteins to form acetaldehyde protein adducts. This not only changes the structure of proteins, but also causes abnormal protein function, glutathione depletion, mitochondrial damage and increased collagen synthesis. It causes hepatocyte inflammation, necrosis and fibrous tissue proliferation. Chinese liver disease society fatty liver and alcoholic liver disease group to formulate the clinical diagnostic criteria for alcoholic liver disease: 1, there is a long-term history of alcohol consumption, generally more than 5 years, the amount of alcohol converted male & ge; 40g / d, female & ge; 20g / d, or 2 weeks with a large amount of alcohol history, the amount of alcohol converted > 8Og / d. But should pay attention to gender, genetic susceptibility and other factors. Alcohol conversion formula: g = alcohol consumption (m1)× alcohol content (%)× 0.8. 2, the clinical symptoms are non-specific, may be asymptomatic, or have the right epigastric distension, loss of appetite, fatigue, weight loss, jaundice, etc.; with the aggravation of the disease, there may be neuropsychiatric, spider nevus, liver palms and other symptoms and signs. 3.Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), total bilirubin (TBIL), plasminogen time (PT) and mean corpuscular volume of red blood cells (MCV) are elevated, and these indexes can be significantly decreased after alcohol abstinence, and usually return to normal within 4 weeks, and AST/ALT>2, which is helpful for diagnosis. 4.The liver ultrasound or CT examination has typical manifestations. 5.Rule out hepatophilic virus infection, drugs and toxic liver injury. Alcoholic liver disease can be diagnosed by meeting items 1, 2, 3 and 5 or items 1, 2, 4 and 5; only meeting items 1, 2 and 5 is suspicious for diagnosing alcoholic liver disease. Treatment of alcoholic liver disease: 1. Abstinence from alcohol. Abstinence from alcohol is a key factor in the treatment of alcoholic liver disease. Abstinence or significant reduction of alcohol intake significantly improves histologic changes and survival in patients at all stages of the disease. 2.Metadoxine accelerates the clearance of alcohol from the serum and helps to improve symptoms of alcoholism and behavioral abnormalities. 3, Glycyrrhizic acid preparations, reduced glutathione, and polyenophosphatidylcholine have varying degrees of anti-inflammatory, antioxidant, and hepatocyte membrane and organelle protection. Several new therapeutic trials are currently underway for inflammatory injury in alcoholic liver disease, with anti-TNF-a antibody having the best therapeutic prospects. 4, Glucocorticosteroids improve survival in patients with severe alcoholic hepatitis. 5, Liver transplantation can be considered for patients with severe alcoholic cirrhosis, and patients are required to abstain from alcohol for 3 to 6 months before liver transplantation.