Patients with gallbladder cancer often have some pain in the advanced stage, especially in the last days before death, and the pain will often be more obvious, even with more severe outbreaks of pain every 1-2 hours. Because of this particular location, it often leads to the final impairment of liver function, as well as obstruction of the hepatic portal of the liver, there will be general jaundice, and the skin on the body, especially the sclera are very yellow, and this condition will lead to chronic wasting plus general malnutrition, and also the manifestation of cachexia. In the final stage, the patient will also show cardiopulmonary failure, coarse and heavy rales, and a lot of popping in the throat, slowly breathing, and some changes in heartbeat, such as nodding-like breathing, or a rapid and slow decline in heart rate and blood pressure. A very small number of patients may also experience an unexpected transient improvement in their mental and spiritual well-being before they die, which is known as a return of light.