The etiology of tumors is still not fully understood, and so is gallbladder cancer. Moreover, the diagnosis and treatment of gallbladder cancer are still very unsatisfactory, and the diagnosis of gallbladder cancer only when clinical symptoms appear is often late and the prognosis is poor, so prevention of gallbladder cancer is very important. Therefore, prevention of gallbladder cancer is very important. We hope that gallbladder-related diseases can be treated before gallbladder cancer occurs. It is well documented that there is an inverse relationship between cholecystectomy and gallbladder cancer mortality. Early cholecystectomy for patients with chronic calculous cholecystitis is effective in preventing the development of gallbladder cancer. It is generally recommended that patients with the following manifestations should be considered for active surgical treatment: 1. patients with obvious symptoms of cholecystitis and gallbladder stones, especially gallbladder stones larger than 2 cm, gallbladder atrophy or obvious thickening of the wall; 2. ultrasound suggesting limited thickening of the gallbladder wall; 3. porcelain-like gallbladder; 4. gallbladder stones combined with polyp-like lesions; 5. gallbladder neck embedded stones; 6. gallbladder tumor-like lesions, especially adenomas larger than 1 cm in diameter or adenomas with thick and short tips; 7, abnormal confluence of bile and pancreatic ducts. For healthy people, regular abdominal ultrasound examination should be performed every year, and if any problem is found in the gallbladder, further examination should be done at an early stage, among which abdominal CT and MRI are more common.