Most of the articles about vitamin C and shrimp eating together can form trivalent inorganic arsenic (commonly known as arsenic) and thus poisoning, and most of them are very mysterious and mysterious. Is this really true? A nurse in my department had such a personal experience, drinking about 400ml of vitamin C-rich fruit orange (equivalent to 30mg of vitamin C) while eating about 200g of shrimp, and was safe. Research data show that although shrimp contain pentavalent inorganic arsenic, but VC alone or Fe ^ 2 + can not reduce pentavalent inorganic arsenic into trivalent inorganic arsenic harmful to humans, only when the concentration of VC greater than 10mmol / L or Fe2 + concentration greater than 20mmol / L, can increase the concentration of 60mmol / L of sulfhydryl compounds in the reduction of sulfhydryl (-SH) (P < 0.01), and the specific presence of sulfhydryl groups (-SH) is often in the form of reduced glutathione (GSH), cysteine (Cys). In other words, it is not so easy to get poisoned, at least three conditions must be met: first, your body concentration of reduced glutathione or cysteine reaches 60 mmol/L; second, you have to eat a concentration of vitamin C greater than 10 mmol/L; third, you have to eat enough shrimp. As a medical practitioner, we need evidence-based medicine, objective biochemical indicators, an empirical spirit, and, more importantly, the ability and trait of independent thinking.