Childhood leukemia is a malignant proliferative disease of the hematopoietic system, mainly caused by viral infection, chemical stimulation, radiation factors, genetic factors, etc. The symptoms of the disease are usually less than 10, and the common symptoms mainly include the following: 1. Fever: usually irregular fever, and lasts for a long time, and in severe cases the body temperature can exceed 40°C or more. Usually caused by the lack of normal white blood cells, the normal defense function of the body is damaged, triggering infection, thus causing fever; 2, anemia: usually caused by the suppression of hematopoietic function or the presence of bleeding in multiple parts of the body. The main manifestations are pallor, weakness, low appetite, etc., and the phenomenon of anemia can be gradually aggravated with the development of the disease; 3. 4, liver, spleen, lymph node enlargement: usually no obvious pain, and lymph node surface without adhesions, smooth, in general, chronic granulocytic leukemia children’s splenomegaly phenomenon is more obvious; 5, bone pain: usually caused by the proliferation of leukemia cells in the bone marrow, or caused by a certain invasion of the periosteum and bone cortex, resulting in children appear sternal pressure pain and joint pain, and mainly manifested in the legs 6, neurological symptoms: If leukemia cells have infiltrated the central nervous system, it can lead to intracranial hypertension, which can cause meningeal leukemia, headache, vomiting, convulsions, coma and other symptoms.