China is a region where hepatitis B is prevalent, and up to 10% of the population is infected with hepatitis B virus. According to clinical observation, the rate of hepatitis B virus infection in babies born to women with positive surface antigen and e antigen can be as high as 88.1%, of which 5% are infected with hepatitis B virus in utero, and most of the rest are infected during the perinatal period by inhalation of maternal blood, amniotic fluid or vaginal secretions. The rate of hepatitis B virus infection in infants born with a single positive hepatitis B surface antigen is 38%. Once infants are infected with hepatitis B virus, 85-90% of them will develop chronic hepatitis B virus status, and 25% of them will die of cirrhosis and liver cancer in adulthood. Therefore, it is very important to interrupt mother-to-child transmission of the hepatitis B virus, which is important to ensure the health of the next generation. Can a woman with the hepatitis B virus become pregnant? What measures can be taken to interrupt mother-to-child transmission of the hepatitis B virus? As early as in the 70s and 80s, developed countries have applied hepatitis B immunoglobulin to block mother-to-child transmission of hepatitis B virus, which has achieved very good results and greatly reduced the number of hepatitis B virus carriers in the population. Since the 1980s, hepatitis B immunoglobulin has also been used clinically in China to solve the worries of hepatitis B mothers in childbirth. According to clinical research, the newborns born to hepatitis B surface antigen-positive pregnant women were not detected positive for hepatitis B surface antigen after repeated intramuscular injections of hepatitis B immunoglobulin from 20 weeks of pregnancy onwards. Therefore, women with hepatitis B virus who are pregnant can receive one injection of hepatitis B immunoglobulin per month from the third trimester onward to effectively protect the fetus. For women who are pregnant and close to delivery, if they are found to be carriers of hepatitis B virus, the newborn baby should be given hepatitis B vaccine immediately within 24 hours of birth, and the dose should be doubled, and then a booster injection should be given one month later and six months later. If the hepatitis B vaccine is given immediately after birth and one month after birth along with one dose of hepatitis B immunoglobulin, the protection rate can be as high as 97.13%. If the mother is given monthly injections of hepatitis B immunoglobulin from the third month of pregnancy onward, the protection rate for her children is even better.