Combined medication for depression is more common, especially for patients in reality, the psychiatric symptoms are more complex, especially will be accompanied by a lot of anxiety, obsessive-compulsive, insomnia, eating disorders and other comorbidities, it is very likely to be involved in the problem of combined medication. The drugs often used: 1, benzodiazepine sedative-hypnotic drugs, the typical representatives of these drugs are lorazepam, oxazepam, alprazolam, clonazepam, etc., have a very good sedative-hypnotic effect, can be used to treat patients with anxiety or insomnia. 2, mood stabilizers, especially for patients with manic tendencies or suicidal behavior, can consider taking lithium carbonate, quetiapine, olanzapine These drugs are used as mood stabilizers. These drugs, as mood stabilizers, can effectively relieve mood instability.3. Anti-psychotic drugs, commonly used are quetiapine, ziprasidone, olanzapine, risperidone, etc. These drugs can effectively relieve the symptoms of depression and enhance the efficacy of antidepressant drugs.4. Chinese herbal medicines can also be used in combination, such as Shu Liver Relief Capsules and An Shen Tonic Brain Solution. These drugs have a certain role in nourishing the qi and nourishing the mind, or alleviating sleep problems and other effects.