There is no definitive treatment for the disease. The main goal is to relieve the symptoms, maintain good posture and slow down the progression of the disease. Since the disease mostly occurs in young people and does not progress at a certain age, it is important to treat the disease early and slow down its progression. Treatment principles should depend on the severity of the disease, prognostic indications and patient expectations. 1, non-pharmacological treatment: ① sleep on a hard bed, supine, side lying alternately, avoid maintaining a posture for a long time, the pillow should not be too high or no pillow. ② Maintain the function of the movement of the spine and joints. In order to maintain the mobility of the thorax, the thoracic and lumbar vertebrae, the patient should often perform deep breathing and chest expansion exercises; in order to maintain the mobility of the hip and knee joints and prevent contracture deformities of the hip and knee joints, activities such as squatting should be performed frequently. ③Strengthen back muscle exercise. You can do more swallow flying movements every day. That is, lying prone on the bed, the neck, upper and lower limbs away from the bed as far as possible online, to exercise the back muscles ④ can do sit-up exercises. 2, drug treatment: (1) non-steroidal anti-inflammatory drugs (NSAIDs) have digestive pain relief, reduce stiffness and muscle spasm effect. (1) Indomethacin (anti-inflammatory pain) 25-50mg 3-4 times a day orally, the drug of choice for the current common. (2) Sulfasalzine (SSZ) SSZ is an azo compound of 5-aminosalicylic acid (5-ASA) and sulfasalazine (SP), which has been used for the treatment of AS since the 80s. The dose was started from 0.25g 3 times daily and increased weekly by 0.25g to 1.0g 3 times daily for maintenance. The efficacy of the drug increased with the duration of administration, and the effective rate of administration was 71% for six months, 85% for one year and 90% for two years. Patients’ symptoms improved, laboratory indices and radiological signs progressed or stabilized. Side effects are mainly gastrointestinal symptoms, skin rash, blood and liver function changes, but they are rare. It is advisable to check the blood picture regularly during the drug administration. (3) Methotrexate (MTX) is reported to have similar efficacy to SSZ, and is given in small doses as shock therapy once a week, with 0.5-5mg for the first week, and then increased by 2.5mg per week to 10-15mg per week for maintenance. The efficacy of oral and intravenous dosing is similar. Side effects include gastrointestinal reactions, bone marrow suppression, stomatitis, hair loss, etc. Check liver function and blood picture regularly during the drug use, and avoid drinking alcohol. (4) Adrenocorticotropic hormone (CS) Generally, adrenocorticotropic hormone is not used to treat AS, but when acute iritis or peripheral arthritis is not treated with NSAIDs, CS can be used for local injection or oral administration. (5) Lei Gong Dou Shen (Trirptrygium wilfordii hook, code T2) Initially, domestic treatment of AS with Lei Gong Dou tincture has anti-inflammatory and analgesic effects. 15-30 ml of 12% Lei Gong Dou tincture is used daily, divided into 3 doses after meals. After the disease is controlled (about 3-6 months), the maintenance amount is changed to 5-10 ml daily or every other day, and later the semi-purified product of Radix et Rhizoma Polygoni (T2) 20 mg is taken orally 3 times daily, which is more effective than the tincture and convenient to take. Side effects include gastrointestinal reactions, leukopenia, menstrual disorders and reduced sperm vitality, which can be recovered after stopping the drug. 3, pain department minimally invasive treatment: drug treatment due to the drug itself there are side effects, and take a long time, the drug is slow to take effect, more patients difficult to accept. Even if they receive treatment, patients often find it inconvenient due to the long-term nature of taking medication and the need for frequent blood tests and other tests during medication. At present, minimally invasive treatment in pain department can be done through intervertebral space block, back “ten” block, sacral block, etc. to inject anti-inflammatory and analgesic drugs directly to the source of inflammation, thus eliminating local inflammation and relieving pain, and then combined with the patient’s own functional exercise to achieve the purpose of alleviating the progress of the disease, improving the quality of life, and then curing the disease. 4.Surgical treatment: It is mainly used for the orthopedic treatment of advanced patients with hip stiffness and severe spinal deformity.