I. Overview The spleen is one of the important immune organs of the body, with functions such as blood filtration, isolation and removal of foreign bodies or pathogens, and production of antibodies by antigenic stimulation. In adults, white blood cells, platelets and red blood cells are produced in the bone marrow, and destruction is done in the spleen. Hypersplenism leads to an increase in the destruction of white blood cells (the body’s main immune cells), platelets and red blood cells, and can lead to serious consequences such as low immune function, bleeding and anemia. There are many causes of hypersplenism, including infections, immune system diseases, cirrhosis, Burkha’s syndrome, portal vein thrombosis, leukemia, splenic hemangioma, lymphoma, etc. There are also some cases of hypersplenism for which no cause can be found. The diagnosis of hypersplenism is not difficult. Hypersplenism can be diagnosed if splenomegaly, hematocrit and bone marrow hyperplasia are found. Splenomegaly can often be detected during physical examination. In early stage of hematocrit reduction, the main manifestations are white blood cell and platelet reduction, which can be manifested as easy infection, gum bleeding when brushing teeth, nose bleeding, or bleeding spots on the skin, which should be alerted to the possibility of hypersplenism. Treatment 1. Treatment of the original disease: The treatment of hypersplenism should first clarify the cause of hypersplenism, and the original disease should be treated to remove the cause. For example, hypersplenism caused by schistosomiasis can be cured by anti-schistosomiasis treatment. For example, if hypersplenism is caused by infection with cornified tuberculosis, anti-tuberculosis treatment can cure hypersplenism. 2. Splenectomy: For patients with unclear primary disease or poor treatment efficacy of primary disease, e.g., hypersplenism after liver cirrhosis can be considered for splenectomy treatment. Splenectomy can quickly solve the problems such as blood cell reduction due to hypersplenism. However, splenectomy also carries many risks, including anesthesia accidents, bleeding, etc. This is because splenectomy is, after all, a surgical procedure that involves opening the abdominal cavity. It has also been shown that children have a significantly higher chance of serious infections after splenectomy. In addition, splenectomy is associated with a high increase in platelets and portal vein thrombosis, so it is important not to cut the spleen if possible. Interventional treatment – partial embolization of the spleen: Interventional technology is a very effective method for treating hypersplenism. Through a very thin catheter, we cut a small 2 mm size opening at the root of the thigh, insert the catheter into the blood supply artery of the spleen through the femoral artery, and partially embolize the spleen to reduce part of the spleen function while preserving part of the spleen function. This resolves hypersplenism while preserving other functions of the spleen, including immune function. 4. Pre- and post-interventional precautions: In order to prevent infection caused by changes in blood rheology after splenic embolization, antimicrobial agents must be used for three days before interventional treatment and must be continued for 5-7 days after surgery to ensure that no splenic abscesses are formed. At the same time, partial embolization of the spleen should not exceed 60% of the total volume of the spleen, otherwise complications such as splenic abscesses are very likely to occur. Embolization can be performed in small portions, which will reduce postoperative reactions and complications. In conclusion, interventional therapy has become a very effective alternative to splenectomy in the treatment of hypersplenism, which is safe and effective without incision.