The duration of treatment required for moderate depression is determined by the individual characteristics of the patient. With sufficient dosage of medication and voluntary cooperation of the patient, the condition will generally improve significantly after 6-12 months of treatment and may be cured. If the patient does not cooperate with the treatment, the condition may further develop into major depression, or even incurable, requiring long-term medication. Moderately depressed patients who cooperate with treatment can be treated by taking antidepressants, such as citalopram, sertraline, paroxetine and other drugs, while cooperating with psychotherapy under the guidance of a psychiatrist to promote recovery. During the treatment period, it is important to follow the doctor’s prescription, take the medication on time, do not change the dose of medication privately, follow the doctor’s advice, and follow up on time, usually 6-12 months can be basically improved. If the patient does not cooperate with the treatment, the family should provide positive guidance to encourage the patient to cooperate with the treatment, and the family should also give the patient full understanding and trust in the doctor. While carrying out treatment, it is also important to pay attention to maintaining good living habits, enriching one’s life and maintaining positive energy. Take part in outdoor activities, hobbies such as walking, fitness, yoga, listening to music, etc., face up to depression, communicate with friends and relatives, maintain a happy mood and good attitude, and have confidence in the treatment.