Several Issues on Antiviral Drug Interruption of Mother-to-child Transmission: I. Problems of mother-to-child antiviral drug blockade for chronic hepatitis B: 1. Chronic hepatitis B married women of childbearing age with abnormal liver function high ALT, HBsAg(+), HBeAg(+) HBV-DNA at 1.0e+7 copies/mL virus highly replicative, or high ALT, HBeAg(-) sex, HBV-DNA also highly replicative, antiviral treatment before pregnancy, according to the specific condition to choose interferon or nucleoside analogues, treatment until liver function is stable, the The virus is undetectable and HBeAg(+) turns to HBeAg(-). If a patient with chronic hepatitis B is pregnant while taking antiviral drugs, the oral pregnancy class B drugs such as telbivudine and tenofovir can be continued with the patient’s informed consent. If you are not taking a pregnancy class B drug, change to a class B drug immediately. Inject hepatitis B immunoglobulin 200iu/time 24 hours (preferably within 6 hours) after the birth of the child, and hepatitis B vaccine 10ug/time according to 0-1-6 months. II. Hepatitis B virus carriers of mother-to-child antiviral drug blocking problems, normal liver function, HBeAg (+) or HBeAg (-), HBV-DNA highly replicated, is in the immune tolerance period, the woman’s pregnancy will turn from immune tolerance to immune activation, liver function appears abnormal ALT elevation, in the second trimester of pregnancy (7 months of pregnancy) available strong, rapid pregnancy B level drugs tipifudin or Tenofovir, (monitor creatine kinase while taking tenofovir), hepatitis B immunoglobulin 200iu/time within 24 hours after the birth of the child (preferably within 6 hours) and hepatitis B vaccine 10ug/time at different sites from 0-1-6 months. The drug can be stopped 1-1.5 months after delivery. The antiviral drug blockage rate can reach about 98%. Prof. Wang Yuming of Southwest Hospital of the Third Military Medical University observed more than 200 cases with almost 100% blockage rate. I am also in the process of observation. Method on Combined Immunity Blockade: Mother-to-child blockade in mothers with double positive HBsAg(+) and HBeAg(+) and mothers with HBsAg(+), HBeAg(-) and highly replicated HBV-DNA: One, inject hepatitis B immunoglobulin 200IU/time subcutaneously 24 hours after the child is born (preferably within 6 hours), and at the same time inject hepatitis B vaccine at different sites 10ug//time, by 0-1-6 months injection. II. Children can also be injected with hepatitis B immunoglobulin 200iu/time 24 hours after birth (preferably within 6 hours), and then injected with hepatitis B immunoglobulin at the same dose one month later. Hepatitis B vaccine 10ug/time, injected at 0-1-6 months. The blockage rate is about 92%. On the mode of delivery of pregnant women: At present, scholars say different things, some think that the infection rate of natural delivery and caesarean section is not statistically significant. However, some think there is still a difference, and I agree with the latter opinion.