Gallbladder stones are mainly seen in adults, more in women than men, and their incidence increases with age after the age of 40. The stones are cholesterol stones or a mixture of cholesterol-based stones and black bile pigment stones. The prevalence of gallbladder stones in our population is about 15%. Medical research has found that the following people are more likely to suffer from gallstones: 1. Women Surveys have shown that female patients account for 70% of gallstones patients, and the cyclical changes of menstruation in women are caused by the cyclical changes of estrogen. It is generally believed that female hormones can change the normal diastolic function of the gallbladder, making the emptying and contraction function of the gallbladder worse in women than in men. Female hormones can also affect the composition of bile, with a decrease in bile acid secretion by the liver and a mild bilious effect. In the early stages of pregnancy, women have poorer than normal gallbladder contraction and emptying function due to pregnancy-related vomiting, inadequate feeding and lack of stimulation by fatty foods in the duodenum. In the latter stage of pregnancy, due to the enlargement of the uterus, the intra-abdominal pressure increases to compress the bile duct excretion, the pressure in the bile duct increases to slow down the emptying of the gallbladder, the gallbladder tends to expand, the viscosity of the bile increases, and the bile stagnates in the gallbladder, creating conditions for the formation of gallbladder stones. Some people also find that in late pregnancy, there is a temporary increase in bilirubin in the blood, as well as an increase in cholesterol and estrogen, which are the etiological basis for stone formation. Therefore, there are more gallbladder stones in women than in men because of the physiological differences between women and men. 2, age factor A survey found that the incidence of stones at the age of 60 is 10 times the incidence of 30 years old, but that explains the incidence, so for older people should have regular medical checkups, check the abdominal ultrasound. If there is stomach discomfort, epigastric pain, nausea and other symptoms to consider gallbladder stones. 3, obese people who weigh more than 15% of the normal standard, the incidence of gallstones is 5 times higher than normal people, the incidence of gallstones in obese women between the ages of 20 and 30 is 6 times higher than their normal weight counterparts, and 40% of obese women over 60 years old have gallbladder disease and gallstones. 4, the diet of meat and sweet people with this diet fat and cholesterol intake, can cause the bile of three kinds of lipid ratio imbalance, cholesterol over-saturation, easy to cause cholesterol stones. The reason why people who love sweet food are prone to gallbladder stones is that excessive sugar intake will increase insulin secretion and accelerate the accumulation of cholesterol, causing an imbalance in the ratio of cholesterol, bile acids and lecithin in the bile, while excess sugar will also be converted into fat, making the body fat, which in turn will increase cholesterol secretion and promote the formation of gallstones, which means that obese people are prone to gallstone disease. 5, people who often do not eat breakfast The bile in the gallbladder is concentrated, stored for a long time, the ratio of three kinds of lipids is out of balance, over-saturated cholesterol to shed cell mucus material as the core, the formation of cholesterol stones. 6.Patients with roundworm infection Roundworm reflux to the bile duct to lay eggs or die will become the core of stones and generate stones. 7.Patients with cirrhosis Related to higher estrogen level in the body of patients with cirrhosis, low contraction function of chronic hemolysis gallbladder, poor emptying, varicose veins of bile duct, and elevated bilirubin in blood.