Pain is a relatively common phenomenon in daily life is also, a common clinical symptom. Headache and nausea are commonly associated with migraine, intracranial occupational lesions, cerebrovascular lesions, etc. Migraine is a common type of headache in clinical practice, the cause of which is not very clear. If necessary, pain relief drugs and physical therapy should be given according to the type of migraine and the nature and degree of pain. Intracranial occupational lesions, such as brain tumors, can cause an increase in intracranial pressure, resulting in headache with nausea and vomiting. If necessary, brain CT or cranial magnetic resonance examination should be done to identify the cause, and conservative treatment or surgery should be given for the cause. Cerebrovascular lesions such as subarachnoid hemorrhage and cerebral hemorrhage can cause severe headache with nausea and vomiting, and should be examined accordingly and treated actively. In summary, there are many causes of headache with nausea, mostly migraine, intracranial occupying lesions, vascular lesions, etc. The causes should be identified and given active treatment.