Recently, Dr. Li Deyu, chief physician of the Department of Hepatobiliary Surgery, led Dr. Yu Haibo, deputy chief physician, and Dr. Dong Yadong, attending physician, to complete four cases of hand-assisted laparoscopic splenectomy, after which all patients recovered successfully from the surgery and were discharged from the hospital. All four patients had upper gastrointestinal bleeding, hypersplenism and previous history of cirrhosis. The patients and their families were concerned about the traumatic nature of the operation and came to our hospital for better treatment. Dr. Li Deyu, chief physician of hepatobiliary surgery, and Dr. Yu Haibo, deputy chief physician of hepatobiliary surgery, completed the relevant examinations, organized a careful discussion among all physicians, formulated a detailed surgical plan, and decided to perform “hand-assisted laparoscopic splenectomy with peripancreatic vascular dissection” for the patient. The postoperative incision was only about 175px long, much smaller than the conventional incision; the patient’s hospital stay was greatly shortened compared with the conventional treatment plan. The conventional splenectomy periampullary vascular dissection is very traumatic, the incision is about 750px long, and the patient’s postoperative recovery is slow. Since 2013, we have carried out full lumpectomy splenectomy and peripancreatic vascular dissection, but we found that the procedure was narrow in scope and incomplete in disconnecting the patient, and there was a possibility of rebleeding after the operation. Now our department uses hand-assisted laparoscopic splenectomy and peripancreatic vascular dissection to achieve the same therapeutic effect as open surgery, while reducing patient trauma, and can be widely performed, providing a better treatment method for portal hypertension.