Not all gallbladder stones can be preserved, and physicians should further determine the appropriate treatment according to the patient’s medical history, the morphology and function of the gallbladder, and the type of stones. According to the efficacy statistics of gallbladder stone removal surgery, combined with the causes of gallstones, gallbladder function and ethical requirements, the indications for gallbladder stone removal should be strictly grasped as follows: 1, no atrophy of gallbladder; 2, gallbladder wall thickness <3 cm, smooth; 3, good contraction function of gallbladder, contraction rate >30%, good bile transmission; 4, no stone obstruction in gallbladder duct; 5, less than 3 gallbladder stones, and diameter <2 6, no acute inflammatory attack; 7, except malignant gallbladder lesions; 8, no polyp-like lesions; 9, no history of upper abdominal surgery; 10, the patient has a clear requirement for biliary preservation and fully understands the possibility of stone recurrence. Patients with family history of gallstones, diabetes mellitus and other metabolic syndromes should be cautiously treated with biliary stone extraction.