Syphilis is a chronic, systemic sexually transmitted disease caused by the syphilis spirochete. In addition to invading the skin and mucous membranes, it can also invade the cardiovascular system and the central nervous system in later stages. In addition, syphilis can have serious consequences for fertility if contracted by a pregnant woman. Syphilis is a sexually transmitted disease that is prevalent worldwide and is currently very prevalent in China. Syphilis testing is required in the following cases: 1. hard ulcers or nodules in the genital area: if this manifestation occurs in about 1 month of non-marital sexual contact history, it is mostly stage 1 syphilis and needs to be tested to confirm the diagnosis. 2, the whole body or the palms of the feet parts of the appearance of multiple erythema, or the pubic and perianal appear more wet papules, and the past history of non-marital sexual contact. This kind of performance may be the second stage of syphilis, and should be promptly detected and treated. 3, young and strong patients suddenly appear neurological diseases, such as cerebrovascular disease, limb paralysis, vision or hearing loss and other manifestations. The possibility of syphilis infection should be considered and syphilis etiology or serology testing is needed to rule out neurosyphilis infection. 4.Sex partners of syphilis patients need to be tested for syphilis. 5, pregnant women with syphilis, and not formally treated, their babies should be tested as soon as possible. 6, syphilis patients in the regular anti-syphilis treatment, need regular follow-up and syphilis serological testing. 7, in addition, previous unprotected high-risk sexual behavior, even if they do not show any abnormalities, it is also necessary to carry out testing for syphilis or other sexually transmitted diseases.