A case of laparoscopic-assisted hepatitis C cirrhosis, portal hypertension, hypersplenism, splenomegaly and giant splenectomy was successfully completed in the Department of Surgery of our hospital. The patient had undergone two biliary tract surgeries due to long-term liver cirrhosis and weakness of the system. Dr. Wang Youli, Associate Chief Physician, in cooperation with Dr. Yang Zhifu, Associate Chief Physician, and Dr. Gao Ju, Attending Physician, performed a TV laparoscopic-assisted giant splenectomy on the right side of the open biliary tract under general anesthesia on September 25, 2008, which lasted 5:30 minutes. The right epigastrium was found to have extensive adhesions below the incision. The spleen was closely adherent to the colonic splenic area and gastric lesser curvature, and the spleen was 12×6×4cm3 in size. The operation was performed smoothly and the postoperative recovery was smooth. Patients with hematologic diseases who are to undergo splenectomy are often combined with thrombocytopenia, so it is difficult to control hemorrhage during splenectomy, and it is more difficult to stop bleeding during LS than OS. Therefore, portal hypertension was once listed as a contraindication to laparoscopic surgery. The successful development of this technology marks that our hospital has already had considerable strength in laparoscopic surgery and has accumulated experience in the minimally invasive process of abdominal surgery in our hospital in terms of high-risk surgery. We have the ability and experience to explore in a broader and riskier field.