Ankylosing spondylitis is one of the common diseases in rheumatology, mostly occurring in young people. If not treated properly or systematically, the disease is disabling and patients can lose their ability to live. I. Definition: Ankylosing spondylitis (AS) is a chronic progressive disease that mainly affects the sacroiliac joints, spinal prominences, paraspinal soft tissues and peripheral joints, and can be accompanied by extra-articular manifestations. In severe cases, spinal deformity and joint ankylosis may occur. Diagnosis: ① the duration of lower back pain lasts at least 3 months, and the pain improves with activity but does not decrease with rest; ② the lumbar spine is restricted in the anterior-posterior and lateral flexion directions; ③ the thoracic extension range is less than the normal value for the same age and sex; ④ bilateral sacroiliac arthritis grade II-IV, or unilateral sacroiliac arthritis grade III-IV. Third, Chinese medicine: Chinese medicine is recorded in the Yellow Emperor’s Classic of Internal Medicine, there is an understanding of strong spine, with the continuous understanding of the disease and the accumulation of experience of successive generations of physicians, the efficacy of treatment has increased. In recent years, the understanding of the disease has been further enhanced. Fourth, their respective advantages and disadvantages Treatment is generally taken during the remission period to tonify the kidneys and pass the ducts, and during the acute period to clear the heat and detoxify the toxins Using non-steroidal anti-inflammatory drugs, immunosuppressants, and biological agents alone or in combination with each other Advantages of each The effect is in 1-4 weeks. Immunosuppressants have a slower onset of action, usually taking effect in 1 month and effective in 3 months. Biological agents have a faster onset of action, around 1 week. Disadvantages The current technology does not allow for a clear elucidation of the theory of TCM and herbal medicine. Also the efficacy varies greatly due to the difference in the ability of TCM doctors to understand this disease. Immunosuppressive drugs can control the disease when used, but at the same time they suppress the body’s immunity, leading to a significant increase in the probability of tuberculosis, tumors and infections in patients. Also patients with strong spine occur mostly in youth, and the use of immunosuppressive drugs can lead to infertility, which may be restored after stopping the drug, but its probability is inconclusive. Also if used during pregnancy, it leads to fetal malformations. Biological agents are just now being used for the treatment of strong spine, their high price makes them economically unavailable for long-term use for many patients, while the specific efficacy on strong spine is still at the stage of clinical trials. Last year at the European annual meeting of rheumatologists, European rheumatologists came to some conclusions about the treatment of strong spine, among which the efficacy of immunosuppressants in the treatment of patients with strong spine with only spondylolisthesis (meaning no lesions in the joints of the extremities, only the accumulated spine) is unclear. In conclusion: I personally believe that in the current clinical treatment of patients with strong spine, only the use of Chinese herbal medicine for internal and external use have achieved good results, generally 1-3 months to control the disease.