Drug-related hepatitis, which is liver damage caused by drugs or their metabolites, is a non-viral hepatitis. Drug-related liver damage is a common cause of liver function abnormalities, but it is not contagious and usually heals quickly with drug withdrawal, rest and liver-protective treatment. The various drugs we take are generally absorbed from the intestine and then reach the liver via the portal vein. The liver is the main organ of drug concentration, transformation and metabolism, especially oral drugs are absorbed from the gastrointestinal tract and enter the liver, and the concentration in the liver is higher than that in the blood and other organs. Due to the toxic effect of drugs and metabolites or allergic reaction of the body to drugs, damage to the liver is caused by drug-related hepatitis. Theoretically, any drug can cause drug-related hepatitis. According to a large amount of information from home and abroad, it has been found that there are more than 600 commonly used drugs with hepatotoxic side effects in varying degrees. Many drug excipients, herbal medicines and health care drugs also have the potential to cause liver damage, which are divided into the following categories according to their commonness: anti-tuberculosis drugs, antibiotics, tumor-related drugs, oral contraceptives, antipyretic and analgesic drugs, some herbal tonics, drugs for cardiac arrhythmia, lipid-lowering drugs, immunosuppressants, drugs for hyperthyroidism, and so on. When drugs are used in excessive amounts or for too long, they can cause damage to the liver. Especially when two or more drugs are improperly combined, the damage is even worse and can cause abnormal liver function. Common manifestations of drug-related liver injury include weakness, anorexia, jaundice, dark yellow urine, and pain in the liver area. Fever, rash, joint pain, muscle pain, etc. may occur in a small number of patients. Usually blood tests will show elevated transaminases, elevated bilirubin, and eosinophilia. If treatment of drug-related liver injury is delayed, the morbidity and mortality rate can be as high as about 10%. If timely diagnosis and treatment, the prognosis is generally good. The combination of prevention and treatment is fundamental. The first thing to prevent drug-related hepatitis is to maintain a high level of vigilance against drug-related hepatitis. Most people with drug-related hepatitis have no obvious symptoms and continue to take drugs without realizing it, which can easily delay the disease. The best way to prevent it is to use drugs sparingly and cautiously (including Chinese, herbal, and tonic drugs) and not to take them on your own. If there are symptoms such as fever, poor appetite, weakness, itchy skin, jaundice, rash, etc., and there was a history of taking medication 1 to 4 weeks before, everyone should think about the possibility of drug-related liver damage. The following points can be taken into consideration: 1. Seek medical advice from a hepatologist as soon as possible. 2. Stop unnecessary medication immediately. Unnecessary medication” means medication that is not prescribed by a physician but that you have purchased or recommended by others. 3. Clarify the name of the medication you are taking and double check that the dosage you are taking is correct. 4, if you have chronic hepatitis B or chronic hepatitis C, no matter which disease you go to the hospital to see, please inform the physician before prescribing the medication to try to avoid aggravating liver damage by taking the medication. 5, herbs, tonic, Chinese medicine is also medicine, do not think that these drugs are “mild” and will not have hepatotoxicity. As long as it is a medicine, there is a possibility of hepatotoxicity. Those who claim to “protect the liver” or “strengthen the liver” prescription, but in fact have hepatotoxicity, please be very careful. 6, should avoid mixing Chinese and Western medicines: some Chinese and Western medicines mixed, its components will react, which will lead to liver damage, leading to adverse consequences, so it is recommended that you should take Chinese and Western medicines separately, time to time to use. 7. Develop the habit of keeping detailed records of medication (including Chinese, herbal and complementary medicines). Detailed medication records can help physicians determine whether liver disease is related to drugs. 8.Some drugs are not very hepatotoxic when taken alone, but may enhance hepatotoxicity when taken in combination. Therefore, each time you visit the doctor, please give a detailed explanation of the current medication (including Chinese, herbal and complementary medicines). 9, should avoid the use of expired drugs: expired drugs are likely to contain certain harmful substances and cause damage to the liver, so we should avoid the use of expired drugs. 10.Should avoid taking western drugs from unknown or unapproved sources: You should avoid taking drugs that do not indicate the manufacturer, drug lot number, drug date and expiration date to avoid damaging the liver. 11.Please abstain from alcohol. Alcohol will strengthen the hepatotoxicity of the drug. 12.Please draw blood to check whether you have viral hepatitis (e.g. hepatitis B, hepatitis C) in order to exclude that the liver disease is caused by hepatitis virus. 13.Liver puncture may be helpful in the diagnosis of drug-related liver disease. If your hepatobiliary specialist suggests you to have a liver puncture, please do not refuse.