Although the exact cause of depression is still far from being completely elucidated, researchers at home and abroad have done a lot of in-depth research on biological or psychosocial factors that contribute to the disease. At present, there is a general consensus among mainstream researchers that the occurrence of depression is the result of the interaction between biochemical, genetic, psychodynamic and social environments. To understand the etiology of depression, it is necessary to consider the combined effect of these factors on the occurrence of depression on the one hand, and on the other hand, it should be recognized that the proportion of the causative factors may vary among individuals with the disorder. Fortunately, some characteristics of people who are vulnerable to depression have been summarized, which can help to prevent the occurrence of depression effectively. Women are the number one susceptible group. The number of depressed patients is at least twice as high in women as in men. The reasons for gender differences may be related to the influence of sex hormones, differences in psychosocial stress between men and women, and different behavioral patterns for coping with stress. Women tend to have more difficult lives than men, encounter more stressful events, and are often in the midst of negative experiences and lack effective coping responses. Secondly, women are also prone to depressive disorders after childbirth due to endocrine effects, which we commonly refer to as postpartum depression or three-day depression. In addition, men are less likely than women to admit to suffering from depression, and they are more worried about being labeled as depressed. Personality characteristics with more obvious anxiety, compulsive, impulsive and other traits of individuals prone to depression, with the performance of excessive suspicion and caution, excessive attention to detail, rules, entries, order or forms, the pursuit of perfection, excessive moral values, cautious, over-valuing the effectiveness of work and disregard for fun and relationships, overly attached to social customs, stereotypes and stubbornness; or the performance of continuous and generalized feelings of tension and anxiety, etc. Adverse childhood behaviors often constitute important risk factors for depression in adulthood. The following experiences have been found to be strongly associated with depression in adulthood: (1) loss of both parents during childhood, especially during preschool; (2) lack of parental care during childhood (e.g., lack of parental care during childhood due to poor parental relationship, separation of parents, prolonged placement of the child with grandparents or boarding school due to parental work or other reasons); (3) childhood abuse, especially sexual abuse (e.g., not being breastfed since childhood); and (4) childhood abuse, especially sexual abuse. other adverse childhood experiences (e.g., living in a relatively closed environment for a long period of time, harsh parents, inability to have normal social interactions, etc.). Unfavorable social environment has an important impact on the occurrence of depression, and these unfavorable social environment factors can be summarized as follows Marital status. Marital dissatisfaction is an important risk factor for depression, and the risk of depression is significantly higher in divorced or separated or widowed individuals than in those with good marital status, with men being more prominent; ②. Economic status: The main members of low-income families are vulnerable to depression: ③. Life events. Significant sudden or life events lasting more than 2-3 months pose a significant impact on the development of depression. Significant life events such as death of a loved one or loss of love can be a direct contributor to depression. Genetic factors are strongly associated with the development of depression. Familial studies have found a significantly higher rate of homozygosity in relatives than in the general population, with a higher consistent rate of onset the closer the blood relationship. In a survey of depressed patients, it was found that approximately 40%-70% of patients have a genetic predisposition, meaning that nearly or more than half of patients can have a family history of depression. Relatives of patients with depression, especially first-degree relatives, have a significantly higher risk of depression than the general population. Older adults are a major component of the major depressive disorder population. The National Institute of Mental Health reports that 10%-20% of elderly depressed patients have major depression; the report also points out that the abuse of opiates, central stimulants, alcohol, sedative-hypnotics and other psychoactive substances is also an important factor in the increasing incidence of depression. It was found that more than 50% of individuals who consume alcohol on a long-term basis have depressive disorders. Somatic diseases, especially chronic central nervous system diseases or other chronic somatic diseases can be an important risk factor for the development of depressive disorders. For example, 2/3 of stroke patients, 40% of coronary heart disease patients and 45% of myocardial infarction patients, 1/4 of diabetic patients, and 40% of oncology patients can have depressive symptoms 2 years after the onset of stroke. Depression can have adverse effects on physical illnesses, such as it can delay recovery from stroke, which can lead to a 30% increase in mortality, induce myocardial infarction, which can increase mortality by 80%; it can lead to worsening of diabetes; it can decrease the survival rate of tumor patients by 20%; depression delays wound healing, which can prolong the hospital stay of surgical patients.