For the treatment of major depression, the first-line clinical treatment is mainly based on pharmacotherapy, especially the application of 5-hydroxytryptamine reuptake inhibitors. 5-hydroxytryptamine reuptake inhibitors, as the first-line drugs of choice for depression treatment, are widely used in the clinic, such as paroxetine, sertraline, fluoxetine, escitalopram, venlafaxine, duloxetine, mirtazapine and other drugs. . In order to achieve the best therapeutic effect in the treatment process, the following principles need to be followed: 1. Adequate amount of adequate course of treatment, systematic and standardized treatment. The so-called full dose in the process of treating the condition of depression patients, the dose of medication to achieve the best and most effective dose, which is very important. 2, full dose in the case of the application of drug therapy 6-8 weeks later to systematically assess the symptoms of depression, according to the results of the assessment to adjust the dose of drugs or increase the amount, or increase the type of drugs and other ways to improve the therapeutic effect. 3, full course of treatment, especially for depression The acute period is not less than 3 months, and the consolidation period is 6-9 months; the maintenance period is 1-2 years for the first depressive episode and 3-5 years for the second depressive relapse, and for depressive relapse more than three times, it is recommended to maintain the dose for treatment for life in medication. These are some basic principles in the treatment of major depressive disorder, which are also the basic guarantee to achieve the treatment effect.