Early syphilis includes stage I, stage II and latent syphilis within two years. Early syphilis is generally selected with benzathine penicillin 2.4 million units, divided into two sides of the buttock intramuscular injection, once a week for two times. For patients who are allergic to penicillin, doxycycline 100 mg each time, twice a day for 15 days can be used. Or ceftriaxone 250-500 mg once a day for 10 days. Late syphilis includes three stages of cutaneous mucosal skeletal syphilis, late latent syphilis or latent syphilis where the stage of the disease cannot be determined and second stage recurrent syphilis. Late syphilis is usually treated with benzathine penicillin 2.4 million units intramuscularly once a week for 3 times. For patients who are allergic to penicillin, doxycycline 100 mg twice a day for 30 days can be used. Patients with cardiovascular syphilis who have heart failure, first treat heart failure, when the heart function can be compensated can be injected penicillin, but start with small doses to avoid the occurrence of Jihai reaction resulting in increased disease or death, neurosyphilis needs to be treated with aqueous penicillin first, then benzathine penicillin for 3 weeks.