Alcoholic liver disease is a disease of the liver that results from long-term heavy alcohol consumption. Alcoholic liver disease includes mild alcoholic liver disease, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. In recent years, the incidence of liver damage caused by alcohol in China is also on the rise year by year, and alcohol has become the second major cause of liver damage after viral hepatitis. Taonan City Hospital of Traditional Chinese Medicine Department of Surgery Yu Nianfeng Alcohol has obvious toxic effects on the liver. The main metabolite of alcohol after entering the body is acetaldehyde. Acetaldehyde can be covalently combined with a variety of proteins to form acetaldehyde protein adducts. This not only changes the structure of proteins, but also causes abnormal protein function, glutathione depletion, mitochondrial damage and increased collagen synthesis. It causes inflammation, necrosis and fibrous tissue proliferation in hepatocytes. The Chinese Society of Liver Diseases Fatty Liver and Alcoholic Liver Disease Group has formulated the clinical diagnostic criteria for alcoholic liver disease: 1. A history of long-term alcohol consumption, generally more than 5 years, with an alcohol equivalent of ≥40g/d for men and ≥20g/d for women, or a history of heavy drinking within 2 weeks with an alcohol equivalent of >8Og/d. However, the influence of gender, genetic susceptibility and other factors should be noted. The alcohol conversion formula is: g = amount of alcohol consumed (m1) × alcohol content (%) × 0.8. 2. Clinical symptoms are non-specific and may be asymptomatic, or may include right upper abdominal distention and pain, loss of appetite, fatigue, weight loss, jaundice, etc.; as the disease worsens, there may be signs and symptoms such as neuropsychiatric, spider nevus, liver palms, etc. 3. Serum aspartate aminotransferase (AST), alanine aminotransferase ( 3. elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), total bilirubin (TBIL), prothrombin time (PT) and mean erythrocyte volume (MCV), etc., which may decrease significantly after abstinence and usually return to normal within 4 weeks, with AST/ALT>2, which helps to diagnose. 4. typical manifestations of liver ultrasound or CT examination. 5. exclusion of hepatophilic virus infection, drugs and toxic liver injury, etc. Alcoholic liver disease can be diagnosed if items 1, 2, 3 and 5 are met or items 1, 2, 4 and 5 are met; alcoholic liver disease is suspected only if items 1, 2 and 5 are met. Treatment of alcoholic liver disease: 1 Abstinence from alcohol. Abstinence from alcohol is a key factor in the treatment of alcoholic liver disease. Abstinence or significant reduction in alcohol intake significantly improves histological changes and survival in patients at all stages.2 Metadoxine accelerates the clearance of alcohol from serum and helps to improve symptoms of alcoholism and behavioral abnormalities.3 Drugs such as glycopyrrolate preparations, reduced glutathione and polyenyl phosphatidylcholine have varying degrees of anti-inflammatory, antioxidant, and hepatocyte membrane and organelle protection effects. Several new therapeutic trials are underway for inflammatory damage in alcoholic liver disease, with anti-TNF-a antibodies showing the best promise.4 Glucocorticosteroids may improve survival in patients with severe alcoholic hepatitis.5 Liver transplantation may be considered in patients with severe alcoholic cirrhosis, requiring patients to abstain from alcohol for 3 to 6 months prior to liver transplantation.