Leukoaraiosis is a chronic systemic vascular inflammatory disease, and its severity needs to be analyzed by integrating the patient’s symptoms. The symptoms are mild and only affect the mucous membranes and skin, which is not very serious; however, some patients can have some digestive tract and vascular system involvement, which is more critical and may even affect life. 1. Light patients: Light patients generally only have basic symptoms, such as oral ulcers, vulvar ulcers and skin lesions, while skin lesions are characterized by erythema nodosum, pseudofolliculitis, acne-like folliculitis and superficial embolic phlebitis. Pseudofolliculitis, acne-like folliculitis, and superficial embolic phlebitis are the main manifestations. These patients do not have serious organ involvement, the disease is often mild, the prognosis is relatively good, in the clinical use of drugs; 2, heavy patients: for severe patients with organ involvement, there can be digestive tract involvement, and in severe cases, perforation of the digestive tract can occur. Neurological system involvement can cause damage to the brainstem, such as intracranial hypertension and spinal cord injury. Injury to the vascular system can result in hemangiomas, vascular embolism, and even vascular rupture, which are often treated surgically. Patients with leukoaraiosis should achieve early diagnosis and be actively given appropriate treatment to prevent serious complications, which can lead to fatal injuries. Patients should also practice regular rest and exercise to promote physical recovery.