In clinical practice, the main parental blood types that often cause hemolysis are: among the ABO blood types, if the pregnant woman’s blood type is O, her husband’s blood type is A, B or AB, and the child’s blood type is A or B, hemolysis of ABO blood type will occur, which is caused by the antigenic reaction, and among the RH blood types, it is more common in the second child. It is recommended that pregnant women do regular pregnancy checkups during pregnancy, especially blood group related checkups, so that the phenomenon of hemolysis can be detected in time, and the disease can be treated in time to control the development of the disease, so as to avoid aggravation of the disease, which can cause serious damage to the child’s health.