Headache to sleep is when the patient has a relatively severe headache that interferes with sleep. Clinically, it can be caused by a variety of diseases, commonly including intracranial tumors and cerebrovascular disease, mainly cerebral hemorrhage and subarachnoid hemorrhage. In addition, it can also be seen in cluster headache, which is a kind of primary neurovascular headache. Most patients present with deep, orbital and periorbital headache on one side of the eye, and can also have burning pain, sharp stabbing pain, tearing and pulling pain in the frontal and temporal areas, and most patients have persistent swelling pain. The headache may be accompanied by conjunctival congestion, nasal congestion, and tearing. Most patients have the onset at night, more often 1-2 hours after going to sleep, and most patients may affect their sleep. The main symptomatic treatment is zolmitriptan or sumatriptan.