The manifestations of depression can be divided into: 1. Core symptoms: depressed mood, lack of interest, and loss of pleasure. 2. Psychological symptoms: anxiety, self-blame, hallucinations, delusions, decreased attention and memory, suicidal ideation and behavior, psychomotor retardation or agitation, etc. 3. Somatic symptoms: sleep disorder, appetite disorder, sexual dysfunction, loss of energy, non-specific somatic symptoms such as pain, peripheral discomfort, autonomic dysfunction, etc. Among them, somatic symptoms are often not given enough attention, resulting in neglected or insufficient treatment, and patients’ symptoms cannot be improved comprehensively, which further affects their quality of life. Sleep disorders are one of the most common symptoms of depression, including: 1) early insomnia (difficulty in falling asleep) 2) middle insomnia (insubstantial night sleep, dreaminess, easy to wake up) 3) terminal insomnia (early awakening) 4) lack of sleepiness, while atypical depressed patients can have insatiable sleepiness; appetite disorders are mainly manifested as decreased appetite and weight loss, which can be manifested as tasteless eating in mild cases, but the amount of food eaten does not necessarily change. Atypically depressed patients can have hyperphagia and weight gain; hypogonadism can be a decreased or complete loss of sexual desire, and some patients can barely maintain sexual behavior but are unable to experience pleasure from it. What physical complaints may be associated with depression? Some depressed patients mainly suffer from somatic discomfort, such as pain symptoms, commonly headache, neck pain, back pain, muscle pain, burning sensation in the stomach, abdominal and urinary pain, etc. Sexual dysfunction is also common in depression, and male patients may experience impotence and premature ejaculation, while female patients show sexual frigidity and lack of sensuality. Some antidepressants themselves may also cause sexual dysfunction, so the clinical recommendation is to use drugs that have less impact on sexual function. In addition, plant nervous disorders are also common symptoms in depressed patients, such as respiratory system symptoms like hyperventilation, sighing, dyspnea, chest suffocation, etc.; circulatory system symptoms like frequent pulse, palpitation, chest discomfort, angina-like attacks, etc.; urinary system symptoms like frequent urination, urine impurity, etc.; digestive system symptoms like nausea, vomiting, stomach discomfort, discomfort in the mouth, abnormal taste, heartburn, hiccups, abdominal distension, etc. symptoms. All of these physical symptoms may be signs of depression. Other common symptoms include thirst, sweating, night sweats, dizziness, and heavy head. Clinically, depressed patients with physical symptoms as the main manifestation often go to the relevant departments of general hospitals initially, resulting in delays or unnecessary medical expenses. Therefore, patients with physical discomfort should be highly suspicious of the possibility of depression if no clear cause can be found, and may want to go to psychiatric or psychological specialists for early detection, early diagnosis and early treatment of depression.