Gout is a clinical syndrome caused by the deposition of sodium urate from supersaturated extracellular fluid into joints, synovial membranes, or other tissues and organs, and includes arthritis, gout stones, uric acid kidney stones, and gouty nephropathy. Refractory gouty stone gout is the result of recurrent episodes of acute gouty arthritis over several years, mostly manifested as chronic, multiple, destructive arthritis with gouty stone formation and/or uric acid kidney stones. These patients are increasing with the increasing prevalence of gout and the low age of onset, and they are more severe, less effective or intolerant to existing drugs, and difficult to treat, so how to effectively treat them is a major issue for rheumatologists.