In recent years, with the rapid development of China’s economy, people’s living standards are improving, from the solution of subsistence to the current diet is very rich, who do not know how much food related to the onset of gout, which led to the development of gout, the former imperial disease, now common disease of the people today, it can be said that “the former king thank the hall before the swallows, flying into ordinary people’s homes This is a true example of how the “former king and his wife have flown into the homes of ordinary people”. The latest survey data show that the number of gout patients in China has more than doubled in recent years, the vast majority of whom are men, and there is a tendency for the age of onset to become younger. Gout, like diabetes, is also a chronic and lifelong disease, as far as the current level of medicine is concerned, it is not yet completely curable, and requires a long-term struggle with the disease, so the diet regimen of gout patients is particularly important. 1.What is gout and hyperuricemia? Uric acid is the end product of purine metabolism in humans. Hyperuricemia (HUA) refers to an elevated blood urate level that exceeds the solubility limit of sodium urate in the blood list (6.8 mg/dl at 37°C). Most epidemiological studies have shown that the upper limit of blood uric acid values is 7 mg/dl (417 μmol/L) in healthy men and 6 mg/dl (357 μmol/L) in women. If the blood uric acid level is >7 mg/dl, the risk of gout starts to increase. 2. Does hyperuricemia mean gout? The answer is obviously wrong. If a patient’s blood uric acid level is >7 mg/dl, but there is no arthritis, gout stone or urate stone, it is clinically called asymptomatic hyperuricemia, the incidence of which is 5%~7% in adult men, and has reached 16.8%~18.3% in Chinese. However, once a patient shows any manifestation of arthritis, gout stones or urate stones, it marks the end of asymptomatic hyperuricemia and the beginning of gout. 3. What are the risks of hyperuricemia? Hyperuricemia is often considered to be a biochemical feature of gout, and its risks include arthritis, kidney stones and interstitial nephritis. In the last 20 years, several large-scale prospective clinical studies have confirmed that asymptomatic hyperuricemia is a risk factor for cardiovascular disease and that blood uric acid levels are strongly associated with all-cause and cardiovascular mortality. 4.How does gout occur? The main reasons for the occurrence of gout are as follows: (1) Genetic factors: Family history of gout or hyperuricemia. (2) Unhealthy diet: Excessive intake of high purine food, which exceeds the body’s metabolic capacity or high-fat diet, which reduces the excretion of uric acid (strictly speaking, high purine diet or high-fat diet is not the root cause of gout, but only a causative factor, the essence of gout is still the metabolic disorder of uric acid). Also, alcohol consumption, especially beer, can easily lead to excessive production or impaired excretion of uric acid, and once uric acid is deposited and crystallized in the local joints, especially in the large joints of the thumbs and other extremities, gout stones will be formed, and patients will suffer from pain during attacks. (3) Infection, trauma and surgery: all kinds of stress may lead to fluctuation of uric acid level and thus induce gout. 5.How to choose uric acid-lowering drugs reasonably? Uric acid-lowering drugs can be divided into three categories: drugs that inhibit uric acid synthesis (such as allopurinol, febuxostat), drugs that promote uric acid excretion (such as propoxur, benzbromarone) and drugs that promote uric acid decomposition (such as labile lyase, polyethylene glycol uricase). Baking soda tablets alkalinize urine to help avoid uric acid crystals precipitation, now also proved that lipid-lowering drug fenofibrate and antihypertensive drugs amlodipine and coxsartan also have the effect of lowering uric acid. According to the condition, complications and systemic condition, we should choose the medication reasonably. I have seen a case of a young male gout patient in Xishuangbanna, who repeatedly took a Thai drug called “Nasa” (actually a non-steroidal anti-inflammatory drug) in the past two years, and then developed severe anemia. anemia. 6.To what level is the uric acid level reduced to be considered as the standard? The purpose of uric acid lowering treatment is to reduce the high blood uric acid level, so as to prevent the formation of new urate crystals and to promote the dissolution of existing crystals. The lower the blood uric acid level, the less gout stones are deposited. Therefore, the recommended target level for uric acid-lowering therapy is 4-6 mg/dl, which is well below the blood uric acid saturation level and should be maintained for a long time or even for life. In conclusion, gout is a treatable and preventable disease, but it is important not to think that everything is fine when the uric acid level decreases and that a single remission of arthritis is a cure for gout, but to be alert to the possibility of recurrence. When patients with hyperuricemia or gout receive uric acid-lowering therapy, it is important to prevent inadequate doses of medication, unclear goals, inadequate courses of treatment and lax follow-ups. In any case, it is important to change unhealthy lifestyles, abstain from alcohol (especially beer), adhere to a long-term low purine diet, avoid a high purine diet such as animal offal and mushrooms, and improve adherence to treatment.