Nearly one month ago, a middle-aged female patient developed hepatocellular carcinoma. The tumor was about 10×5 cm, located in the left half of the liver, affecting the first and second hepatic hilum, with abdominal lymph nodes and retroperitoneal lymph node metastasis, but no tumor was seen in the right half of the liver. Due to the compression of the stomach by the left hepatic tumor, the patient’s feeding was seriously affected. The family requested active treatment to prolong the patient’s life. Due to the large size of the tumor, the radiotherapist consulted and concluded that radiotherapy was not effective. We performed a left hemicolectomy for the patient, which completely removed the left liver tumor. Intraoperative ultrasound re-exploration did not reveal the right liver tumor, and the postoperative recovery was smooth, and the pathology was moderately differentiated cholangiocarcinoma. The patient has been discharged from the hospital to recuperate and is in good condition. The success of this surgery should significantly prolong the patient’s life. For the surgical treatment of malignant tumors, there are radical resection and palliative (subtractive) resection. In cases where the tumor has spread distantly and metastasized and radical resection is not possible, palliative resection with postoperative radiotherapy, chemotherapy, radiofrequency ablation or interventional therapy, and other comprehensive antitumor measures can also significantly prolong the patient’s life in some patients. We have a male hepatocellular carcinoma patient who has survived for more than 6 years after a combination of surgery, intervention, radiofrequency ablation, and drug anti-cancer treatment, and is still living with tumor.