Gallbladder cancer can be divided into three stages: early stage, middle stage and late stage, each of which has different clinical symptoms. Patients with gallbladder cancer should understand the symptoms of each period to detect the changes of the disease in time, so as to provide early treatment and avoid deterioration of the disease. 5 early symptoms of gallbladder cancer: 1. Right upper abdominal pain: Most of them are persistent pain in the right upper abdomen, which can be intensified paroxysmally and radiated to the right shoulder and waist back. This symptom accounts for 84%, because gallbladder cancer mostly coexists with gallbladder stones and inflammation, so the nature of pain is similar to that of stone cholecystitis. 2. Gastrointestinal symptoms: The majority of cases (90%) have dyspepsia, aversion to grease, belching, and reduced gastric capacity, which is due to the inability of the gallbladder to renew its function and digest fatty substances. Nausea and vomiting are also quite common, and there is often loss of appetite. 3.Jaundice: Due to the spread of cancer, about 1/3 to 1/2 of the patients develop jaundice. In a few patients, jaundice is the first symptom, and most of the jaundice appears after pain, and the jaundice is persistent and progressively aggravated. Most of them are due to malignant obstruction caused by the invasion of bile ducts by cancerous tissues. It is accompanied by emaciation, weakness and even cachexia, yellow staining of skin and mucous membranes, with untreatable itching of skin. 4.Chill and fever: Mostly appear in the late stage of cancer, 25.9% of the patients have fever, and may have high fever persistently. 5.Other: accompanied by jaundice, abdominal pain and other symptoms, there will also be such as nausea, vomiting, emaciation, deep yellow urine, such as soy sauce or strong tea-like, light yellow stool or even clay color, etc. Extension: The following patients with gallstones should be considered as high-risk groups for gallbladder cancer: middle-aged and elderly female patients with gallstones; patients with long duration of disease, with a history of gallstones for more than 5 years; patients with gallstones, with limited thickening of the gallbladder wall as indicated by ultrasound; patients with gallstones larger than 1 cm in diameter and embedded stones; patients with gallstones, with recent pain in the gallbladder area of the upper abdomen becoming persistent pain and significant weight loss.