It is a chronic infectious disease caused by syphilis spirochetes, which can invade almost all organs of the body, and is highly contagious in the early stage, mainly invading the skin and mucous membranes, often manifesting as genital ulcers, swollen lymph nodes and a generalized rash; in the late stage, it is devastating, often causing damage to the cardiovascular system and the nervous system. The disease is mainly transmitted through sexual contact, a few through blood transfusion, contaminated household utensils, pregnant women with syphilis can also infect the fetus, causing miscarriage, premature birth, stillbirth and delivery of congenital syphilis children. However, it should be noted that some patients may not have any symptoms in the early stage. Treatment: Early, regular and complete treatment and regular follow-up. Precautions: 1. Seek proper medical treatment: go to regular hospitals for examination and treatment to avoid misdiagnosis and mistreatment. 2. Early detection and early treatment can avoid important organ damage. 3, if there are suspicious symptoms: genital ulcers, rash should be promptly to the regular hospital to confirm the diagnosis. 4, adhere to the rules, the whole treatment. 5. It is important to follow up regularly as instructed. 6.Sexual partners should be treated and followed up at the same time. 7. Avoid sexual intercourse during treatment. 8.If you have any problem during the treatment (drug reaction, fever, etc.), you should go to the regular hospital for examination and consultation. 9.Check whether other STDs are combined: AIDS, soft chancre, genital herpes, etc. 10. Considering marriage and pregnancy, it is better to wait for cure and follow up after 2-3 years. 11.The correct use of condoms can effectively prevent syphilis.