Headache is a very common clinical condition, and the causes of headache are complex, but in general, benign diseases are more common. For example, frequent migraines are commonly caused by vascular neurological diseases. Rhinogenic and ophthalmogenic headaches are caused by sinusitis, glaucoma, and other nasal and ocular diseases. Some malignant tumors, such as glioblastoma, have recurrent headaches as the first symptom, and brain metastases, such as lung cancer or breast cancer, sometimes have frequent headaches as the first symptom. In addition, some malignant tumors outside the brain may also have frequent headaches. For example, patients with acute leukemia may have frequent headaches due to infection and fever, as well as other symptoms such as weakness and vomiting. In conclusion, many diseases, including malignant tumors, can cause headaches. If you have frequent headaches, you should go to the hospital for examination to clarify the cause and treat it early.