Radical surgery for gallbladder cancer was performed on a 78-year-old woman this morning. The doctor recommended surgery for the gallbladder stone that was detected 5 months ago due to abdominal pain, but Liang had not undergone surgery because she was afraid. I considered the possibility of gallbladder cancer to be very high, and with my explanation and persuasion, Liang and her family finally agreed to be hospitalized for surgery. After the preoperative preparation, the gallbladder was removed this morning under general anesthesia, and the intraoperative pathology confirmed that it was “hypofractionated adenocarcinoma of the gallbladder with multiple stones”. With the high malignancy of gallbladder cancer and poor prognosis, Liang’s family was very sad: “I thought it was just some small stones, how did the gallbladder become cancerous?” As a common disease, gallbladder stones are easily overlooked. Some patients have been mistaken for stomach diseases and blindly take medicine without careful examination; some think they can get better with injections and medicine, and only choose surgery when inflammation and abdominal pain are difficult to control with medicine; some are reluctant to undergo surgery for fear of surgery; some patients even believe in biased prescriptions and blindly perform long-term “stone removal” and “stone reduction”. Unbeknownst to them, gallbladder stones without timely treatment will not only increase patients’ pain, medical expenses and the difficulty of surgery, but also cause gallbladder cancer. Gallbladder stones are an important cause of gallbladder cancer, and more than 90% of gallbladder cancer patients are accompanied by gallbladder stones. Generally, the following conditions should be considered as high-risk groups of gallbladder cancer: firstly, obese women, especially those over 50 years old; secondly, those who have gallbladder stones for more than 5 years; thirdly, those with stones over 2.0 cm or filled gallbladder stones as indicated by ultrasound. Gallbladder cancer, commonly known as “100-day cancer”, is highly malignant, metastasizes early and progresses fast, but there is no specific clinical manifestation in the early stage, and it is not easy to distinguish it from chronic inflammation in imaging, so it is difficult to make early diagnosis. ”Upper medicine treats the untreated disease”. For ordinary people, prevention of diseases is very important. Reasonable regulation of diet, regular life, proper exercise and avoidance of gaining weight prevent gallbladder stones and reduce the causative factors of gallbladder cancer. For middle-aged and elderly women with gallbladder stones, if they are usually asymptomatic, it is recommended to review ultrasound once every six months. If the condition recurs, they must seek medical treatment in hospital as soon as possible, especially for high-risk groups. If gallbladder stones are found to be larger, grow faster and more numerous, gallbladder removal surgery should be performed as soon as possible to prevent cancerous changes.