However, in clinical practice, we often encounter many patients who have had one or more ultrasound-guided prostate puncture biopsies, although their PSA is above the normal range, and the pathology still does not reveal “cancer cells”, but finally prostate cancer is diagnosed by other means. This phenomenon seems to indicate that routine prostate puncture biopsy is not a “sparse” net and that some prostate cancers are always missed. In fact, this is true because routine prostate puncture is still an empirical “no-target” sampling, whether the puncture is done transrectally or perineally. This poses a problem. This poses a problem, as many prostate cancer lesions are actually small, or even hidden in the “nooks and crannies” of the prostate, which can easily be missed by the “traditional” method of prostate puncture. It is possible to say that the targeted puncture technique is a technological leap forward in prostate puncture surgery, which has solved many of the problems that our clinicians have, and has also brought good news to many patients who have been worried about having prostate cancer all day. The “targeted puncture” of the prostate is not a combination of expensive high technology, it is actually the result of the joint efforts of our urologists and imaging doctors. The following is a brief introduction to the targeted puncture technique for the prostate. Everyone has heard of MRI. In fact, MRI has great application in the detection of prostate cancer, and some experienced prostate cancer treatment centers are fully capable of reaching the level of locating cancer lesions inside the prostate through MRI. However, this is not to say that a random MRI is all that is needed, because MRI is a very complex test that involves the adjustment of dozens of parameters, and different parameter adjustments can directly affect the sensitivity of the “detection” of prostate cancer. The sensitivity of the MRI will be directly affected by the adjustment of different parameters. We often encounter patients who come to us with MRI reports from other hospitals and are misdiagnosed with prostate cancer due to improper settings of the test parameters. After the MRI has revealed a suspicious cancer lesion inside the prostate, the rest is the job of our urologists. In order to “right” such a suspicious lesion during the puncture procedure, we need to make a series of careful plans based on the location of the lesion, including the entry point of the puncture needle, the timing of the trigger, the depth of the puncture, and so on. With the development of technology, especially with computer fusion technology and three-dimensional reconstruction (3D printing) technology, such “targeted puncture” technology has become possible. To facilitate the implementation of this “targeted puncture” technique, we also use computer software to overlay the MRI information with the ultrasound images during the puncture process. This targeted puncture technique with “navigation” can be used to observe the MRI image at any time during the puncture process and puncture to the suspicious location, which can be said to be “where to hit”. The above is a brief introduction to the new technology of targeted prostate puncture. With the use of this technique, we have found prostate cancer in many patients who had missed multiple punctures in the past. A patient with the surname Mao, 65 years old, had 5 routine systemic punctures for elevated PSA in the last 3 years, but no prostate cancer was found. After visiting our hospital, multiparametric MRI and new tumor markers in blood and urine were highly suggestive of prostate cancer. Finally, we persuaded the patient to undergo another “targeted puncture” of the prostate, not with many needles, but only with 3 needles for the suspicious lesion, and as a result, the tumor was found in all 3 needles. The “targeted puncture” technique can help us diagnose prostate cancer at an earlier stage by accurately locating and puncturing the suspicious lesion, which has enabled many patients similar to Mr. Mao to be diagnosed early and treated in a timely manner. We sincerely hope that this technique will be well mastered by doctors in other hospitals as soon as possible and widely carried out, so that more patients can benefit from it.