Generally speaking, the preferred treatment drug for syphilis in clinical practice is penicillin, which controls disease progression by preventing repeated regeneration of syphilis spirochetes cell walls, and therefore syphilis spirochetes are highly sensitive to penicillin. However, the duration of treatment and the number of treatments need to be analyzed according to the types of penicillin drugs and the severity of syphilis, not necessarily only three applications of penicillin. I. Types of drugs: Among the types of penicillin, the commonly used one is benzathine penicillin, which is generally applied 3 times to achieve better efficacy. Procaine penicillin, on the other hand, needs to be used continuously for about 20 days, but the specific number of times needs to be judged by a professional doctor according to the condition. Second, the severity of syphilis: 1, early syphilis: the disease is light, the relative treatment time and number of times is short, generally benzathine penicillin through intramuscular injection 3 times, procaine penicillin continuous treatment for 10-15 days, you can control the development of the disease to some extent; 2, late syphilis: due to the heavier disease, treatment time is long, benzathine penicillin needs to be applied 3-5 times continuously, and procaine penicillin through intramuscular injection , which requires about 20 days of continuous treatment. If the disease is not well controlled and the titer test result is persistently above 1:4, the treatment time should also be extended under the guidance of a doctor. In addition, some people have drug resistance, even the application of benzathine penicillin for the treatment of early syphilis, the effect is still limited, need to extend the treatment time according to the situation. It should also be followed up closely and reviewed regularly for 3 years, once every 3 months in the first year, once every 6 months in the second year, and once at the end of the third year, in order to observe the effect of syphilis treatment and thus ensure complete cure. Pay attention to the disinfection and protection of personal belongings, and exercise properly to enhance physical fitness.