Gallbladder cancer takes the first place among malignant tumors of gallbladder, other than sarcoma, carcinoid tumor, primary malignant melanoma and giant cell adenocarcinoma. The prognosis of this disease is poor, and even if the tumor is surgically removed, the prognosis is still unsatisfactory. Gallbladder cancer has no specific clinical manifestations in early stage or only symptoms of chronic cholecystitis, so early diagnosis is very difficult, and once persistent pain in upper abdomen, jaundice and other lesions have reached advanced stage, various examinations are also abnormal. Especially for middle-aged and elderly patients over 50 years old, those with gallbladder stones and inflammatory polyps should undergo regular ultrasound examination for early and clear diagnosis. So, what are the symptoms of gallbladder cancer? The following are the symptoms of gallbladder cancer. 1.Gastrointestinal symptoms: Most of the patients (90%) have indigestion, aversion to greasy belching and reduced appetite, which is due to the inability of the gallbladder to digest fatty substances. 2, fever: 25.9% of patients have fever. 3.Pain in right upper abdomen: this symptom accounts for 84% because gallbladder cancer mostly coexists with inflammation of gallbladder stones, so the nature of pain is similar to that of stone cholecystitis. 4.Mass in right upper abdomen: 54.5% of the cases have a mass in the right upper abdomen or epigastric region when the lesion is in advanced stage. Firstly, the rapid growth of tumor obstructs the bile duct and enlarges the gallbladder; secondly, the obstruction caused by invasion of duodenum and the symptoms of obstruction appear at the same time; in addition, the invasion of liver, stomach and pancreas can also appear corresponding parts of the mass. 5.Jaundice: jaundice often appears in the late stage of the disease, accounting for 36.5% of cases due to malignant obstruction caused by cancerous tissues invading the bile ducts, accompanied by emaciation, weakness and even cachexia.