There may be several reasons why depression is severe in the morning: First, it may be related to the existence of circadian rhythm disorder in the secretion of some neurotransmitters in patients, such as the secretion of thyroid hormone, pentraxin, dopamine and other hormones. Second, it may be because depressed patients have poor sleep at night, for example, patients may have difficulty falling asleep or maintaining sleep, and wake up more than two hours earlier than usual in the morning, which may also cause severe depression in the morning. Third, it may be related to the patient’s mood, it is more difficult to cope with the daytime need to cope with the study, work, social and other tasks, the patient will have this daunting mood, do not want to get up, and do not want to go to activities.