Syphilis is a chronic systemic disease caused by the syphilis spirochete. If syphilis is not treated in time, it can lead to the involvement of various organs of the body, including the heart, liver, brain, blood vessels and nerves, which seriously endangers the health of patients. Syphilis is divided into early syphilis and late syphilis according to the course of the disease. Early syphilis includes stage 1 syphilis and stage 2 syphilis. The first stage of syphilis is the occurrence of one or several painless hard nodes or shallow ulcers on the external genital area, called “hard chancre”, accompanied by non-purulent enlargement of inguinal lymph nodes, i.e. “syphilis cross-craft”; after 3-8 weeks, the hard chancre can subside on its own without treatment. The syphilis spirochete then enters the bloodstream from the lymphatic system, leading to second-stage syphilis. Syphilis is mainly manifested as skin, mucous membrane, bone, internal organs, cardiovascular and neurological damage; among them, skin and mucous membrane damage is complex and variable, and clinical symptoms are very similar to many skin diseases, so it is easy to misdiagnose. The rash is often symmetrically distributed, except for flat warts with a slight itching sensation, generally no conscious symptoms, no certain specificity. If early syphilis is untreated or inadequately treated, after a minimum of 3-4 years and a maximum of about 20 years, about 20% of syphilis patients can develop stage 3 syphilis. In addition to clinical damage to the skin and mucous membranes and bone, it can also invade internal organs, especially important organs such as the cardiovascular, brain and central nervous system, which can be life-threatening. In addition, patients with latent syphilis do not have any clinical signs and symptoms of syphilis except for positive blood tests, so they are most likely to be missed or misdiagnosed, in short, syphilis is a complex and serious sexually transmitted disease. In recent years, the incidence of syphilis in China is on the rise, prevention and health education is urgent and imperative. Stage I syphilis diagram Stage II syphilis diagram