Craniopharyngioma surgery is relatively risky. Because the tumor is often closely attached to the pituitary stalk and inferior optic thalamus, these two structures, especially the inferior optic thalamus, are particularly sensitive to surgical traction and other manipulations, often resulting in severe postoperative reactions. Currently, there are two views on the surgical treatment of craniopharyngioma. One advocates complete resection, even at the expense of pituitary disease; the other advocates major or subtotal resection under the premise of safety. The author prefers the latter, because the treatment means for brain tumors are much richer now than 10-20 years ago, and there are more means to treat the residual tumors. There is a patient with suprasellar craniopharyngioma with a large tumor, for which the author performed surgical resection one year ago, and about 80% of the tumor was removed. After the surgery, the residual tumor was treated with radiofrequency knife in 2 months after surgery, and the residual tumor shrank by 40% after 6 months. The author does not emphasize that craniopharyngioma is not treated by total resection. It is only to emphasize that there are more treatment means, and we can achieve the purpose of controlling tumor growth by combining multiple treatment means, instead of risking to pursue total resection.