Liver hemangioma, generally no need to treat, only larger than 10cm or have obvious pressure symptoms, there are indications for surgery! However, if the hemangioma is too large, surgery is relatively difficult, and if it is close to a large blood vessel, it is even more difficult and even life-threatening. In this case, a 47-year-old woman surnamed Huang had a huge hepatic hemangioma, 16x12x10cm, spanning the three liver segments IVa, VIl, and Vlll of the left and right livers, with the middle hepatic vein attached to the inside and the right hepatic vein compressed at the back, which made surgical resection extremely risky! If the irregular right triple (right hemihepatic + IVa) resection is performed, lVb is preserved, which facilitates the surgeon’s surgery, but the resection scope is too large, sacrificing the V, Vl segments, which is prone to postoperative hepatic failure! If only for hemangioma resection, it is necessary to remove Va, VIl, Vlll, according to the international difficulty standard score, according to the size of the tumor, the relationship with the blood vessels, and the location of the liver segment, all three are the highest difficulty, the doctor is not only a technical test, but also a psychological test! After thorough discussion and perfect preoperative preparation, we decided to perform a combined resection of IVa, VIl and VIll. Under the guidance of Dr. Jiang Bo, we first laparoscopically pre-positioned the Pringer blocking band, dissected and separated the right hepatic artery and the right branch of the portal vein, selectively blocked the blood flow from the right half of the liver into the liver, opened the blood flow from the left half of the liver, and applied ultrasound and Ligsure knives to complete the resection of the complex triple-segmental hepatic giant hemangioma! In anticipation of a large amount of intraoperative bleeding, an autologous blood transfusion device was used to recover 1000 m1 of lost blood, which was filtered and re-transfused after anticoagulation. The safety of the operation was guaranteed. The postoperative vital signs were stable in the wood, and the postoperative HB was 11.9g/l. The success of laparoscopic surgery in this complex case breaks the combined resection laparoscopic no-go area of high IVa, VIl and VIll segments, and brings hope for resection of patients with giant liver hemangiomas, but the risk of the surgery is great, and it is advisable to be cautious!