1. Vertical transmission from mother to child. 2.High viral load. 3.Combined with fatty liver. 4. Combined with alcoholic liver. 5, Combined with cirrhosis of the liver. 6, Combined with HIV infection. 7. Liver transplantation. 8, Combined with obesity. 9, Combined with autoimmune disease can not use interferon. 10, Combined with diabetes mellitus. For this kind of patients, do not wait for drug resistance or poor response and then combine drugs, the initial treatment should be lamivudine and adefovir (Herceptin + Herve Leigh), the economic conditions of the poor can choose domestic. If you are in poor financial condition, you can choose domestic drugs. Or you can switch to domestic drugs to consolidate the treatment when the virus becomes negative. Young people are not convenient to use interferon with a low viral load can choose a single drug lamivudine, four weeks to check the HBV-DNA does not see the effect of the immediate combination of ahdfovir.