Oral drug anti-hepatitis B virus drug treatment: e.g. lamivudine, tibivudine, entecavir, single use of any one of them. Poor response occurs, such as one year of medication, the big three suns turn into 1-5 positive, or still big three suns do not turn, HBV-DAN turned negative, liver function is normal. All can be combined on adefovir. The economic conditions of the beginning of the initial treatment on the combined treatment. If the above situation occurs with adefovir alone, it can be combined with any of the above three kinds. Combination of tibivudine is better. The chances of tibivudine major triple positive to minor triple positive and interferon compared to the United States, there are oral interferon called. Cirrhotic patients are better off not using entecavir because of its animal carcinogenicity. Cirrhosis is inherently more likely to be cancerous than non-cirrhotic people.