In patients with major depression, organic changes have occurred in brain cells, thus requiring lifelong medication to control symptoms. For treatment, there are three options: pharmacotherapy, physical therapy and psychotherapy. Medications are based on selective 5-hydroxytryptamine reuptake inhibitors, such as paroxetine hydrochloride, fluoxetine, sertraline, etc. The drugs have few side effects, good safety performance and can be used for long-term maintenance treatment. If patients experience depression such as hallucinations and delusions, they can be combined with antipsychotic drugs, such as fenadine and sulpiride. Physiotherapy is based on electroconvulsive therapy and can be supplemented with transcranial magnetic stimulation. Psychotherapy, which is a treatment with a longer treatment period, tends to make patients lose confidence in treatment, so patience is necessary and family members should accompany more. It can be combined with marriage and family therapy, cognitive behavioral therapy and other comprehensive treatment. There is also a therapy, which is exercise therapy, allowing patients to adhere to running, rope skipping, walking, tennis, etc.. Patients themselves must learn to adjust, learn a new skill, go out for socializing, and listen to soothing music.