Patients with major depressive disorder show sluggish thinking, we will find that the patient’s thinking, association speed is significantly slowed down, and the patient’s brain is slow to react. The patient’s brain is like a glue or a rusty machine, it is slow and the thinking is closed. Therefore, in clinical practice, patients with major depressive disorder may find that their speech is significantly reduced, their speech speed is significantly slowed down, and their voice is significantly lower, so it is more difficult to communicate with them. In more severe cases, patients may not speak, move, or eat, and may have a depressive mute state, in which communication with the patient is basically impossible. In addition to the problem of thinking, the severity of thinking is further aggravated by the patient’s depressed mood, which eventually leads to a significant decrease in social and occupational functions such as work, study, and life.