Hepatitis B after the onset of treatment is the key to early scientific treatment, half a year without effective recovery will be transformed into chronic hepatitis B. Hepatitis B virus is very mutable, at the same time, due to the emergence of drug resistance of hepatitis B virus and the defects of traditional treatment technology, conservative treatment is nearly “ineffective”, virus toxicity and harm gradually increased, and it has become the characteristics of the new stage of hepatitis B virus and the difficulty of clinical treatment. Immune tolerance, viral replication Due to the infection of hepatitis B virus, the body’s immune mechanism produces a certain degree of immune tolerance, that is, the relative weakening of the immune function. The body’s immunity decreases, leading to rapid and massive replication and spread of hepatitis B virus in the early stage, and at this time, it is generally difficult to be detected through the symptoms, which becomes an important factor in the harm of hepatitis B. Mutation and tolerance, no effective drugs Because of the unique mutation and easy tolerance of hepatitis B virus, inappropriate and unscientific clinical treatment methods increase the speed of virus mutation and the degree of drug resistance. This has led to the weakening of the therapeutic effects of traditional treatments and antiviral drugs, or even the loss of their therapeutic effects. Currently, there is a lack of a single, effective drug. Viral mutation, misdiagnosis and mistreatment After viral mutation, it is not possible to analyze which of the four regions of HBV, C, P, S, X, has mutated, as well as the type and characteristics of the mutated strains, so it is not possible to correctly guide the clinical treatment, which leads to the diagnosis of the disease and the treatment of the program produces the wrong results. For example, if the gene mutation in the S region is negative for HBsAg, the treatment should be maintained; the gene mutation in the X region is closely related to the occurrence of liver cancer, which should be highly emphasized and prevented. This is also one of the current treatment problems. The traditional treatment detection system (PCR, HBV DNA, ELISA) can no longer effectively analyze the complex replication of the constantly mutating HBV in the body, as well as the state of development. It is not possible to monitor the effectiveness of the treatment, nor is it possible to measure and control the effect at the right time, thus limiting and affecting the dynamic observation and correction of the treatment. Other subjective misunderstandings such as delaying the disease mechanism, losing the good opportunity for treatment, misunderstanding, turning negative is recovery. Misconceptions about medication, improper traditional treatment, treatment misconceptions, hepatitis B need to be treated, etc. exacerbate the harm of hepatitis B, increase the damage to liver cells and increase the difficulty of treatment. In this case the traditional treatment technology not only does not have the ideal effect, but also easy to further damage the liver cells in the treatment, leading to the continuous replication and mutation of the virus, toxicity and harmfulness continue to increase. Only through the cutting-edge biotechnology and other modern high-tech means can we effectively contain and clear the hepatitis B virus, effectively control the development of hepatitis B, and fundamentally promote the recovery of the liver.